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INTRODUCTION Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by amyloid-β (Aβ)-mediated neurotoxicity, impaired autophagy-lysosomal function, and neuronal apoptosis. Although sulforaphane (SFN) has demonstrated neuroprotective properties, its molecular actions against Aβ-related ne...
INTRODUCTION Obesity is highly prevalent in schizophrenia (SCZ) and contributes to unfavorable clinical and cognitive outcomes, yet its underlying metabolic mechanisms remain unclear. We applied non-targeted metabolomics to characterize body mass index (BMI) related metabolic signatures in chronic SCZ. METHODS A tota...
The findings identify disrupted right amygdala-MFG connectivity as a potential neural correlate of symptom heterogeneity in MDD, particularly in patients with anxiety symptoms.
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