Uric acid-associated psychopathology in first-episode drug-naïve schizophrenia stratified by depressive symptoms.

Compensatory neurochemical adaptation in first-episode, drug-naïve depression: Integrating cortical and systemic metabolism using multivoxel 1H-MRS.

Findings suggest a possible compensatory neurochemical pattern associated with low BMI in depression, however, the cross-sectional design cannot determine whether this pattern reflects compensatory adaptation or a pre-existing neurobiological subtype, and low BMI alone should not be interpreted as evidence of metabolic...

Sex-stratified associations between depressive symptoms and cognitive impairment in treatment-resistant vs. non-resistant schizophrenia.

Polygenic risk for schizophrenia predicting age-specific fluctuations in depressive symptoms: Findings from the Young Finns Study.

Depressive symptoms in adolescence may represent intermediary phenotypes or transdiagnostic susceptibilities related to high polygenic risk for schizophrenia (PRSscz), which appears to explain age-specific fluctuations in depressive symptoms.

Exploring the association between brief evaluation of psychosis symptom domains and HbA1c in patients with schizophrenia and schizoaffective disorder.

BACKGROUND Patients with schizophrenia have an elevated burden of type 2 diabetes mellitus (T2DM), but the relationship between psychiatric symptom domains of schizophrenia and glycemic status has been less well established. This study aimed to investigate the association of clinical factors with HbA1c in this populati...

Psychotic symptom burden and serum uric acid as correlates in a limited-adjustment analysis of current suicidal ideation in schizophrenia: a cross-sectional study

Suicidal ideation is common in schizophrenia, but simple approaches combining symptom severity with routine biochemical measures remain limited. Serum uric acid, the end product of purine metabolism, is a routinely available peripheral measure linked to antioxidant activity, oxidative-inflammatory processes, and me...

Parkinsonism and psychopathology severity in real-world outpatients with schizophrenia: A cross-sectional PRISM study.

Extrapyramidal symptoms (EPS) have been described as intrinsic to schizophrenia spectrum disorders (SSD), beyond medication-induced effects. Among EPS, parkinsonism is the most prevalent subtype and has been linked to poorer clinical and functional outcomes. We aimed to examine the relationships between parkinsonism an...