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Author

Sheng-Kai Hsu

2 papers indexed here

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#protein folding Open access Sep 2026

3D chromatin remodeling during domestication defines novel targets for crop improvement.

This study provides a resource for redefining precision-breeding paradigms by harnessing cryptic 3D chromatin targets by decoupling sequence-level from chromatin-level selection and shifting the subgenome expression balance of 39 homoeologs in cultivated cotton.

Xian-Hui Huang, Ya-Bing Peng, Xiu-Bao Hu et al. · 0 citations
Open access Aug 2026

PlantCAD2: A DNA foundation model for interpreting genomes across flowering plants

Summary Flowering plants (angiosperms) exhibit extraordinary species diversity, ∼200-fold variation in genome size, and relatively compact coding regions, presenting both a unique challenge and opportunity for DNA language models. Here, we introduce PlantCAD2, an extended-context, plant-specific DNA language model with...

Jing-Jing Zhai, Aaron Gokaslan, Sheng-Kai Hsu et al. · 1 citation

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