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Shi-Jie Wang

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#protein folding Review Open access Oct 2026

Survey of the human proteostasis network: the autophagy-lysosome pathway.

The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, a highly interconnected system of over 3000 components that regulate protein synthesis, folding, localization, and degradation....

Evan T. Powers, Suzanne Elsasser, Ee Phie Tan et al. · 0 citations
Review Open access Oct 2026

Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging

Most neurodegenerative diseases reflect patient-specific combinations of polygenic risk variants interacting with aging and environmental factors, rather than a single causative mutation. Phase III clinical trial failure rates for neurodegenerative indications exceed 95%, reflecting in part the limitations of existing...

Shi-Jie Wang, L. Elia, Wei-Yi Liu et al. · 0 citations

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