Aug 2026
RanBP2 promotes ferroptosis resistance and compromises therapeutic response by stabilizing SLC7A1 through LRSAM1 SUMOylation and ubiquitination in lung adenocarcinoma.
This study demonstrates that RanBP2 exhibits elevated expression in LUAD and correlates with poor prognosis, and identifies a novel RanBP2-LRSAM1-SLC7A11 axis that promotes ferroptosis resistance and LUAD progression.
Shi-Wei Guo, Yu Zeng, Qinfen Zhang et al.
· Cell Death and Differentiati... · 0 citations