AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
This study demonstrates that RanBP2 exhibits elevated expression in LUAD and correlates with poor prognosis, and identifies a novel RanBP2-LRSAM1-SLC7A11 axis that promotes ferroptosis resistance and LUAD progression.
Lung adenocarcinoma (LUAD) is one of the major subtypes of non-small cell lung cancer (NSCLC), but the molecular mechanisms underlying LUAD initiation and progression remain incompletely understood. In the present study, we identified TRIM46 as a key driver of LUAD progression. TRIM46 is significantly overexpressed i...
It is demonstrated that heat shock protein 90α (HSP90α) is markedly upregulated in CRC and promotes lung metastasis by suppressing ferroptosis and combined treatment with LeA and the ferroptosis inducer RSL3 further alleviates lung metastatic burden in vivo.
Findings uncover an OTUD4-FXR1-HIF1A signaling axis that promotes glycolysis, which in turn functionally drives gastric cancer progression, and thereby provides a potential prognostic biomarker and therapeutic target.
Our previous studies have established that PDZ and LIM domain 2 (PDLIM2) played an inhibitory role in the progression of hepatocellular carcinoma (HCC). However, the underlying regulatory mechanisms remain incompletely understood. In this study, we identified ADP-ribosylation factor-like 14 effector protein (ARL14EP)...
Findings reveal a previously underappreciated mechanism of CDDP resistance driven by the FTO/SNHG9/VHL/EZH2/PINK1/Parkin axis and support the therapeutic potential of targeting this pathway in LUAD.
EIF2AK2, also known as PKR, is a stress-responsive kinase that regulates multiple cellular processes, including autophagy, apoptosis, and tumor progression. However, the mechanisms underlying EIF2AK2 stability and function in bladder cancer (BLCA) remain underexplored. In this study, we investigated the mechanisms gove...
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