Author

Shi-Zhen Wang

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Open access Oct 2026

Activation pathway of the human voltage-gated proton channel

This work determines the activation pathway of hHV1, together with structural models of its resting and activated states, using an approach that integrates all-atom continuous constant-pH MD (CpHMD), weighted-ensemble (THE AUTHORS) path sampling, and AlphaFold modeling.

Ming-Zhe Shen, Daniel Kortzak, Christophe Jardin et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Regulation of the human voltage-gated proton channel by membrane sterols

This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.

Shuo Han, R. Duan, Sarah Applewhite et al. · bioRxiv · 0 citations