Author

Shinya Kawano

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Sep 2026

Upamostat potentiates bortezomib cytotoxicity and delays proteasome recovery in bortezomib-resistant malignant lymphoma cells through modulation of the DDI2/NRF1 axis.

Proteasome inhibitors such as bortezomib (BTZ) are potent against hematological malignancies, but acquired resistance remains a major obstacle to durable clinical responses. DNA damage-inducible 1 homolog 2 (DDI2)-mediated processing of nuclear factor erythroid 2-related factor 1 (NRF1) contributes to adaptive proteaso...

Atsumi Ota, Sota Maruyama, Yudai Kudo et al. · Biochimica et biophysica act... · 0 citations

Sep 2026

Identification of a small-molecule inhibitor of nardilysin and its pharmacological effects on transcriptional regulation and inflammatory arthritis.

Nardilysin (NRDC) is a zinc metallopeptidase of the M16 family that participates in diverse biological processes, including ectodomain shedding and antigen processing. NRDC also functions as a transcriptional coregulator, and this coregulatory activity depends on its metallopeptidase catalytic function. However, small-...

Yasutaka Amano, Kiyoto Nishi, Hazuki Sano et al. · Biochemical Pharmacology · 0 citations

#protein folding Open access Sep 2026

Efficient Discovery of Potent AKR1B10 Inhibitors Using Co-folding Model Boltz-2

Although affinity prediction of protein–ligand binding remains an important challenge, cofolding models are expected to make virtual screening more effective for drug discovery and development. To verify the effectiveness of selecting a tractable number of candidates from a compound library using cofolding models, we...

Shinya Kawano, Akira Ikari, Satoshi Endo et al. · Journal of Chemical Informat... · 0 citations