Jul 2026
Integrated transcriptomic and experimental validation reveal that N‑acetylcysteine ameliorates acute liver failure through multi‑target synergistic regulation of pyroptosis and related signaling networks.
NAC exerts a comprehensive hepatoprotective effect that surpasses that of a simple pyroptosis inhibitor by synergistically modulating pyroptosis, apoptosis, cell cycle, inflammatory recognition, and endocytosis pathways through multiple targets.
Hua-Zhu Wei, Shubing Yuan, Ziyuan Liang et al.
· Naunyn-Schmiedeberg's Archiv... · 0 citations