Integrated transcriptomic and experimental validation reveal that N‑acetylcysteine ameliorates acute liver failure through multi‑target synergistic regulation of pyroptosis and related signaling networks.

Hua-Zhu Wei Shubing Yuan Ziyuan Liang Qing-Lan Shi

Jul 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 32 references

Medicine

TL;DR

NAC exerts a comprehensive hepatoprotective effect that surpasses that of a simple pyroptosis inhibitor by synergistically modulating pyroptosis, apoptosis, cell cycle, inflammatory recognition, and endocytosis pathways through multiple targets.

DOI PubMed Semantic Scholar

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