AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
This study integrated network pharmacology, transcriptomics, and proteomics to elucidate the protective mechanisms of FF against ALI and revealed that 11 core components mediated anti-ALI effects by modulating 347 targets across 25 signaling pathways.
CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.
This integrative approach confirms that WZDP confers therapeutic benefits in MASLD through coordinated regulation of neuroactive ligand–receptor interaction, bile acid biosynthesis, phospholipase D signaling, and arginine–proline metabolism.
BACKGROUND Current pharmacotherapies for chronic kidney disease (CKD) are limited by adverse effects and a "one-target-one-drug" paradigm. Necroptosis is a key driver of renal deterioration, yet its regulatory network remains poorly defined. Modified Da-Huang-Fu-Zi Decoction (DHFZ) has shown clinical efficacy, although...
Results suggest SYH mitigates ALI by inhibiting the pro-inflammatory TLR4/MYD88/NF-κB pathway and activating the antioxidant Keap-1/Nrf2/HO-1/NQO1 pathway.
Network pharmacology and molecular docking were used to predict BBR targets and pathways, followed by in vivo validation in a methionine- and choline-deficient diet-induced mouse model, suggesting that BBR alleviates MCD-induced steatohepatitis through multi-target regulation of hepatic metabolic dysfunction, immune re...
SDFE can ameliorate LPS-induced ALI by inhibiting leukocyte adhesion and reducing oxidative stress, and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that leukocyte adhesion and oxidative stress are two key signaling pathways involved in the therapeutic effects of SDFE against ALI.
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