Aug 2026
CFTR regulates lipid metabolism by relieving adipose inflammation in obesity.
Jie-Yi Du, Chuan-Feng Ke, Jingbo Chen et al.
· International Journal of Obe... · 0 citations
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Sep 2026
Sodium tanshinone IIA sulfonate attenuates pulmonary vascular remodeling by targeting DYRK1A in pulmonary hypertension.
BACKGROUND Pulmonary hypertension (PH) is a progressive disorder marked by elevated pulmonary artery (PA) pressure and vascular remodeling, often leading to right heart failure. A key feature is pulmonary artery smooth muscle cells (PASMC) phenotypic switching from a contractile to a synthetic state, which drives media...
Zheng-Wei Dong, Qian-Qian Lu, Zhi-Feng Xue et al.
· Phytomedicine · 0 citations
Jul 2026
USP15-mediated deubiquitination of FIS1 impairs mitochondrial function and sensitizes bladder cancer cells to radiotherapy
USP15 plays a critical role in regulating radiosensitivity, and targeting USP15-mediated mitochondrial OXPHOS may represent a promising therapeutic strategy to enhance the efficacy of radiotherapy in bladder cancer, providing a novel treatment approach for the treatment of bladder cancer patients.
Ru-Xin Xiong, Ming-Xu Wang, Jiaming Du et al.
· Oncogene · 0 citations