Skip to content
Log in
Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

USP15-mediated deubiquitination of FIS1 impairs mitochondrial function and sensitizes bladder cancer cells to radiotherapy

Ru-Xin Xiong Ming-Xu Wang Jiaming Du Bing-Qian Chai Qianqian Zhou Ya-Ting Yan Jiang Han Yang Yao Chao Liu Jia-Ni Yang Bojun Wang Shui-Jie Li Yuan-Fei Yao Ruiqi Liu
Jul 2026 · Oncogene · Vol 45, pp. 3765 - 3781 · 0 citations · 57 references
Medicine

TL;DR

USP15 plays a critical role in regulating radiosensitivity, and targeting USP15-mediated mitochondrial OXPHOS may represent a promising therapeutic strategy to enhance the efficacy of radiotherapy in bladder cancer, providing a novel treatment approach for the treatment of bladder cancer patients.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Jan 2026

CCND1 Stability Regulated by USP7 Deubiquitination Controls Glioma Radioresistance via Ferroptosis

Dysregulation of Cyclin D1 (CCND1) is implicated in various cancers, but its specific contribution to glioma radioresistance and the associated regulatory mechanisms remain largely unexplored. This research aimed to elucidate the functional role and underlying mechanisms of CCND1 in glioma radioresistance. Our findings...

Ya-Yu Zhuo, Chen-Rui Zhang, Xiao-Yu Li et al. · 0 citations
Open access Sep 2026

The deubiquitinating enzyme USP42 promotes lung adenocarcinoma progression through PTGS2

The ubiquitin-specific peptidase 42 (USP42) is a cysteine-dependent deubiquitinase with pro-tumorigenic roles in several cancers. In lung adenocarcinoma (LUAD), elevated USP42 expression correlates with advanced stage and poor survival, mirroring the prognostic impact of prostaglandin-endoperoxide synthase 2 (PTGS2) ov...

Hai-Nan Ye, Ji Shen, Dan Liu et al. · 0 citations
Aug 2026

USP16 promotes osteosarcoma progression by stabilizing ESRRA to enhance mitochondrial oxidative phosphorylation.

Osteosarcoma is a highly aggressive primary bone malignancy, yet the underlying mechanisms driving its metabolic reprogramming remain incompletely understood. In this study, we identified ubiquitin-specific protease 16 (USP16) as a critical oncogenic driver in osteosarcoma. Bioinformatics analysis showed that USP16 was...

Zhong-Lun Liu, Xuan Liu, Yi-Fan Gao et al. · 0 citations
Open access Aug 2026

CPT1A-driven USP44 K543 succinylation promotes esophageal squamous cell carcinoma progression via inhibiting CDK5RAP3 K166 deubiquitination.

Ubiquitin-specific proteases (USPs) function in multiple types of tumor progression by controlling protein turnover. However, the regulatory mechanism of ubiquitin carboxyl-terminal hydrolase 44 (USP44) in esophageal squamous cell carcinoma (ESCC) remains incompletely understood. Here, we show that USP44 expression cor...

Guo-Qing Zhang, Long Qiu, Kaiyuan Li et al. · 0 citations
Oct 2026

USP36-mediated stabilization of NAT10 promotes osteosarcoma progression via ac4C-dependent KIF23 mRNA stabilization.

Osteosarcoma is an aggressive bone malignancy with a propensity for pulmonary metastasis, yet the molecular mechanisms linking protein homeostasis to epitranscriptomic regulation remain incompletely understood. Here, integrated transcriptomic, survival, protein-interaction, and CRISPR dependency analyses identified the...

Yan-Fei Wu, Li-Ping Ma, Zhao-Qi Chen et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.