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Open access Sep 2026

Hemodynamic disruption triggers glomerular barrier injury via endothelial glycocalyx degradation in nephrotic syndrome

Nephrotic syndrome (NS) is characterized by heavy proteinuria and is frequently accompanied by a hypercoagulable, hemorheologically abnormal state. Although glomerular filtration barrier (GFB) failure is central to proteinuria, the contribution of altered microhemodynamic cues to endothelial barrier injury remains inco...

Ye Feng, Shuo Wang, Yun-Lai Wang et al. · 0 citations
Sep 2026

TET2 promotes monocyte inflammatory activation in asthma via ALKBH5-m6A regulation and PI3K signaling: evidence from m6A-SNP and single-cell analyses

This study establishes TET2 as a key m6A-regulated gene linking genetic susceptibility to monocyte-driven inflammation, and highlights the ALKBH5-m6A-TET2 axis as a potential therapeutic target for modulating aberrant immune responses in asthma.

Zun Wang, Qian Wang, Yu-Qin Sa et al. · 0 citations

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