Sep 2026· Zeitschrift für Induktive Abstammungs- und Vererbungslehre· Vol 301· 0 citations· 45 references
Medicine
TL;DR
This study establishes TET2 as a key m6A-regulated gene linking genetic susceptibility to monocyte-driven inflammation, and highlights the ALKBH5-m6A-TET2 axis as a potential therapeutic target for modulating aberrant immune responses in asthma.
OBJECTIVE
This study examines the role of serine/arginine-rich splicing factor 1 (SRSF1) in airway inflammation in asthma and the molecular mechanisms in mitophagy and metabolic homeostasis in regulatory T cells (Tregs).
METHODS
Bronchoalveolar lavage fluid (BALF) was collected from asthma patients and healthy contro...
Chun-Hua Ye, Yi-Fu Chen, Qin-Jun Yi et al.· Clinical and Experimental Ph...· 0 citations
Chronic obstructive pulmonary disease (COPD) is asyndrome characterized by airflow limitation, and its pathogenesis is not fully understood. This study intends to conduct a systematic analysis of the key cellular and metabolic remodeling mechanisms involved in the occurrence and development of COPD. A murine COPD model...
Qing-Shuang Mu, Qin Luo, Ye Yang et al.· Biochemical Pharmacology· 0 citations
BACKGROUND
Asthma is a heterogeneous chronic inflammatory syndrome, with the T2-high endotype defined by robust type 2 immune responses and skewed T helper polarization. Although H3K9 acetylation (H3K9ac) is a key activating histone mark in T helper differentiation, its genome-wide promoter landscape in circulating imm...
Daniel González, Alexis Infante, L. López-Kleine et al.· Molecular Immunology· 0 citations
Inflammatory monocytes are increasingly recognized as key amplifiers of psoriasis, yet the epigenetic drivers of their pathogenic signature remain unclear. The mechanisms linking epigenetic regulation to metabolic reprogramming in monocyte-driven inflammation in psoriasis are poorly defined. We examined the expression...
Aman Damara, Najla Abassi, D. Mihoc et al.· Cell Communication and Signa...· 0 citations
PURPOSE
Long non-coding RNA five prime to Xist (FTX) is considered a regulator for asthma. Therefore, we aimed to explore its more roles and molecular mechanisms in asthma process.
METHODS
Serum samples from controls and asthmatics were collected. Asthma mouse models were induced with ovalbumin (OVA), and cell models...
Yu-Ting Lai, Guo-Qing Qiu, Na Li et al.· Allergy Asthma and Immunolog...· 0 citations
Asthma is a heterogeneous airway disease in which chronic inflammation, epithelial barrier injury, immune-cell imbalance and airway remodeling interact to shape variable clinical phenotypes. N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, has emerged as a dynamic epitranscriptomic...
Wu-Fei Ye, Jingrui Ye, Bohan Wang et al.· Epigenomics· 0 citations
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