Causal adiposity and clinical validation of regional fat distribution in PMOS: a multi-modal analysis integrating GBD 2021, Mendelian randomization, and machine learning.
Adiposity, particularly regional fat distribution, appears to be a clinically relevant determinant of PMOS, and the convergence of global epidemiological patterns, genetic evidence, and clinical prediction supports the importance of body-composition phenotypes beyond conventional obesity measures in understanding PMOS...