Causal adiposity and clinical validation of regional fat distribution in PMOS: a multi-modal analysis integrating GBD 2021, Mendelian randomization, and machine learning.

Genetic and Body Composition Factors Associated with Metabolic-Associated Steatotic Liver Disease: A Cross-Sectional Analysis of a Health Screening Cohort

Introduction Metabolic-associated steatotic liver disease (MASLD), newly defined in 2023, is characterized by excessive hepatic triglyceride accumulation in the presence of cardiometabolic risk factors. The body roundness index (BRI), an indicator of body fat distribution and visceral adiposity, has been proposed as a...

Multilevel genome-wide analysis reveals shared genetic architecture between acute pancreatitis and body fat distribution.

BACKGROUND Acute pancreatitis (AP) is a heterogeneous inflammatory disease, and its risk and severity may be shaped more by body fat distribution than by overall obesity. However, the shared genetic basis between AP and depot-specific fat accumulation remains unclear. METHODS We meta-analyzed AP genome-wide association...

Obesity, Insulin Resistance, and Infertility in Women with Polyendocrine Metabolic Ovarian Syndrome: A Retrospective Cohort Study at a Tertiary Referral Medical Center in Qatar

Background: Polyendocrine Metabolic Ovarian Syndrome (PMOS), previously known as Polycystic Ovary Syndrome (PCOS), is one of the most common endocrine disorders affecting women of reproductive age and represents a major cause of infertility worldwide. It is associated with hormonal imbalance, ovulatory dysfunction, and...

Current Understanding of Genetic Architecture of Polyendocrine Metabolic Ovarian Syndrome (PMOS) - 2026 Update.

The PMOS GWAS identified 120 genomic regions significantly associated with PMOS, and the genes encoded by PMOS GWAS loci are implicated in gonadotropin secretion and action, folliculogenesis, sex hormone function, age at menopause, adiposity, insulin signaling, T2DM, calcium signaling, endocytosis, lipid and cholestero...

Serum biomarkers for the diagnosis and management of adolescent polyendocrine metabolic ovarian syndrome: a systematic review and meta-analysis

Summary Background Adolescent polyendocrine metabolic ovarian syndrome (PMOS) poses immediate and lifelong risks to women’s health. However, reliable biomarkers for adolescent PMOS remain elusive in current clinical practice. Methods We systematically searched six databases from inception to April 2026, following PRISM...

Waist-to-height ratio as a practical indicator for screening pediatric metabolic dysfunction-associated steatotic liver disease in diverse populations and genetic backgrounds