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Si-Ji Chen

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#gene editing Aug 2026

Lipopolymer Nanoparticle‐Mediated In Vivo CRISPR‐Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic‐Associated Steatohepatitis

A liver‐targeted lipopolymer nanoparticle‐mediated gene editing platform is developed to enable in vivo disruption of Mrg15 by co‐delivery of Cas9 mRNA and Mrg15 sgRNA to identify Mrg15 as a disease‐relevant epigenetic regulator in MASH and highlight liver‐directed P64H LPNP/CRISPR delivery as a promising non‐viral str...

Zixi Zhang, Jing Liao, Ting-Feng Yu et al. · 0 citations

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