Antimicrobial resistance among Gram-negative bacteria poses a critical challenge to global public health. A key factor contributing to this resistance is their unique outer membrane (OM), which serves as a formidable barrier to many antibiotics, particularly hydrophobic and high-molecular-weight compounds. The OM not o...
Urjoshi Chattoraj, Ayesha Fatima, Deepanshi Saxena et al.· Drug Discovery Today· 0 citations
Gramicidin S (GS) is a cyclic decapeptide that primarily targets Gram-positive bacteria and due to its hemolytic toxicity, is mainly used for the topical treatment of eye, ear, and throat infections caused by S. aureus. Due to its unique mechanism of action, no clinically significant resistance to GS has been reported...
Harshita Dubkara, Swechchha Singh, Rahul Maitra et al.· European journal of medicina...· 0 citations
Given the rapid spread of antibiotic resistance worldwide, it is imperative to develop new strategies against pathogenic bacteria. Here, we report a small-molecule inhibitor of bacterial heat shock protein 70 (Hsp70), called DnaK, a central component of the bacterial protein chaperone network. Screening of an in-house...
Tulsi Upadhyay, Reshma Kumari, Yogesh M. Gangarde et al.· ChemBioChem· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
