Ubiquitously expressed chromatin regulators orchestrate cell-type-specific gene expression programs, yet how they acquire distinct regulatory functions during development remains fundamentally unresolved1,2. Using temporally controlled protein depletion during human cortical neurogenesis in vitro, we show that the auti...
K. Kasliwal, K. Chatterjee, V. Bocchi et al.· bioRxiv· 0 citations
Using cell lines in which ACLY is localized to either compartment, it is found that ACLY in either location supports fatty acid synthesis and histone acetylation, yet compartment-localized ACLY enables finer control, providing more precise regulation.
Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al.· Science Advances· 0 citations
Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent cell properties and impairs their immune...
Rebecca Sereda, Kristen Lindenau, Antonio Díaz et al.· Nature Aging· 1 citation
Chemical modifications of RNA provide an additional regulatory layer essential for development. N6A methyladenosine (m6A) is the most abundant internal mRNA mark, but how site specificity, stoichiometry, and cellular context together determine mRNA fate remains unclear. Here, we define these rules in cardiogenesis by c...
Shun-Yao Lei, H. Gangrade, Sheetal Bajpayi et al.· bioRxiv· 0 citations
Findings identify CARM1 as a regulator of GSC developmental programs and NGFR/NTRK-dependent survival and a role for CARM1-dependent NFIA methylation in NGFR repression in NGFR repression.
Dejauwne L Young, Stephanie Stransky, Maria G Molero et al.· Cell Reports· 0 citations
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