Sm Faysal Bellah

Association of CYP3A5 Genetic Variants With Elevated Breast Cancer Risk: A Case–Control and In Silico Analysis

Background Cytochrome P450 3A5 (CYP3A5) is a key xenobiotic‐metabolizing enzyme that also participates in the biotransformation of endogenous substrates. Functional genetic variation within CYP3A5 can alter enzyme activity and may consequently modify individual susceptibility to malignancy. The contribution of CYP3A5 g...

Impact of EXO1 (K589E) Genetic Variant on Breast Cancer Risk: Evidence From Bangladesh

Exonuclease 1 ( EXO1 ) is a key nuclease in the DNA mismatch repair (MMR) pathway and is involved in correcting replication errors while maintaining genomic stability. The K589E (rs1047840) single nucleotide polymorphism (SNP) of EXO1 has been associated with cancer susceptibility in different populations....

CRISPR–Cas9 genome editing: technological advances, delivery strategies and precision engineering of primary cells for therapeutic application in genetic disorders and diabetes mellitus