Author

Stephen H. McLaughlin

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#protein folding Open access Oct 2026

A generalizable method for the purification and biophysical characterization of bacterial membrane receptors

Abstract Membrane‐embedded bacterial receptors are challenging to express and purify in soluble form, yet their isolated domains are essential tools for structural and ligand‐discovery studies. Pseudomonas aeruginosa relies on the TonB‐dependent heme receptor HasR for iron acquisition, a process central to its pathogen...

Federico Bosetto, M. Zacharopoulou, M. Bycroft et al. · Protein Science · 0 citations

Open access Sep 2026

De novo design of flexible protein interactions with GuideFlip

De novo design of protein binders requires a target structure. However, for flexible targets, such as intrinsically disordered proteins, this structure does not exist until the binder has stabilized the interaction. Such targets are therefore difficult for methods that separate structure generation from sequence design...

Kai Yi, Qing-Chao Chen, Dong-Qi Zhang et al. · bioRxiv · 0 citations

Open access Aug 2026

A generalisable method for the purification and biophysical characterisation of bacterial membrane receptors

A generalizable workflow for producing soluble receptor domains from membrane proteins is established and validated HasR constructs suitable for downstream ligand-screening applications, including aptamer and nanobody discovery.

Federico Bosetto, Maria Zacharopoulou, M. Bycroft et al. · bioRxiv · 0 citations