Subashchandrabose Chinnathambi

Chemokine receptor CX3CR1 modulates microglial activity through Tau and amyloid-β interactions in Alzheimer's disease.

The extracellular Zinc-finger ubiquitin-binding domain of histone Deacetylase 6 enhances podosome formation in neuronal cells.

Mechanistic insights on HDAC6 ZnF UBP-Tau interaction through biophysical and computational approaches.

The findings in this study helps to advance the current understanding of regulatory role of HDAC6 specifically in Tau biology and further provides a useful framework for investigating the modulation of aggregation prone proteins via protein-protein interaction in neurodegenerative diseases.

G-Protein coupled receptor-mediated internalization and endosomal sorting of Tau-GPCR complex in microglia.

Neuronal lipid composition regulates distinct states of full-length tau assembly, mechanics and membrane interactions

Zinc-finger ubiquitin-binding domain of histone deacetylase 6 modulates Tau structure and function.

Comprehensive insights into Alzheimer's disease: Amyloid-β pathology, tau dysfunction, and neurodegenerative mechanisms.

Signaling cascades of microtubule-associated protein Tau in Alzheimer's disease.

This review highlights the major signaling cascades involved in Tau PTMs and its interlinked role in mitochondrial damage in aging population in AD.

iPSC-derived neurospheres: A cellular platform for Tau and Alzheimer's disease immunotherapy.

iPSC-derived neuron, microglia, and astrocyte are used as models to study the spreading of pathological proteins and their contribution in the disease progression, providing insights into disease progression and potential therapeutic targets for neurodegenerative disease.

Small molecular therapeutic targets for neurodegenerative diseases.

A deeper understanding of aging-associated molecular dysfunction is essential to design sustainable, disease-modifying therapeutics with cross-disease relevance.