Signaling cascades of microtubule-associated protein Tau in Alzheimer's disease.

Comprehensive insights into Alzheimer's disease: Amyloid-β pathology, tau dysfunction, and neurodegenerative mechanisms.

Novel therapeutic inhibitor targeting dysregulated kinase signaling in tau-mediated neurodegeneration

This review emphasizes the roles of kinase signaling pathways in tau mediated neurodegeneration and suggests ERK1/2 as an interesting therapeutic target and further research is needed to assess the translatability of ERK1/2 targeting strategies for disease modifying treatment in tauopathies.

The small giant actor in the pathogenesis of neurodegenerative diseases: Microtubules

Therapeutic Strategies for Alzheimer's Disease Targeting Tau Protein and Microtubule Axis

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex course, and at present, only symptom management is available. Given that microtubule disassembly and neuronal toxicity caused by Tau hyperphosphorylation and aggregation are central to the onset and progression of AD, targeting the "Tau...

Region-dependent regulation of Tau phosphorylation in a mouse model of tauopathy

GDE2 is identified as a component of the complex regulatory network that controls Tau phosphorylation in the context of tauopathy and provides insight into putative pathways relevant to Tau pathologies observed in disease.

Microglial dysfunction and NLRP3 inflammasome signaling in Alzheimer’s disease: mechanistic insights into neuroinflammation and neurodegeneration

Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...