Malnourished children are susceptible to an increased risk of mortality owing to impaired immune functions. However, the underlying mechanism of altered immune functions and its interaction with malnutrition is poorly understood. This study investigates the immune function and evaluates the effect of a particular nutri...
Zannatun Noor, M. Hasan, Md. Amran Gazi et al.· Scandinavian Journal of Immu...· 6 citations
Background and objective Serological screening with a confirmation through biopsy has improved the understanding of coeliac disease (CD) epidemiology worldwide. Prevalence of CD in Bangladesh is not yet explored and therefore, we aimed to assess the seroprevalence of CD in slum-dwelling malnourished children and adults...
Md. Amran Gazi, Subhasish Das, M. Mahfuz et al.· BMJ Open Gastroenterology· 4 citations
Abstract. Chronic exposure to infectious agents results in environmental enteric dysfunction—a significant contributor to childhood stunting. Low plasma tryptophan (TRP), increased kynurenine (KYN), and KYN–TRP (KT) ratio are associated with infections and chronic immune activation. We postulated that both these condit...
Md. Amran Gazi, Subhasish Das, M. A. Siddique et al.· American Journal of Tropical...· 26 citations· ⚡1
Abstract Purpose Studies revealed that silencing of low-density lipoprotein receptor-related protein-1 (LRP1) expression can cause inhibition of adipogenesis in animal model and contribute to reduced body size. But there is no study that has explored the association of LRP1 with body mass index (BMI) of human adults. T...
M. Hasan, S. M. Fahim, Subhasish Das et al.· Biomarkers· 3 citations
Background Because Helicobacter pylori (H. pylori) infection and Environmental Enteric Dysfunction (EED) follow a similar mode of transmission, there can be a complex interplay between H. pylori infection and EED, both of which can influence childhood growth. We sought to investigate the factors associated with H. pylo...
S. M. Fahim, Subhasish Das, Md. Amran Gazi et al.· PLoS Neglected Tropical Dise...· 18 citations
Background: The changes of plasma retinol binding protein 4 (RBP4) level after a nutrition intervention can indicate the metabolic changes associated with the delivered intervention. Objective: We investigated the changes in plasma RBP4 level among 12- to 18-month-old children after a nutrition intervention and measure...
Subhasish Das, Md. Amran Gazi, M. Hasan et al.· Food and Nutrition Bulletin· 4 citations
Background Environmental enteric dysfunction (EED) is thought to occur from persistent intestinal inflammation. Studies also revealed the association of lipocalin-2 (LCN2) and low-density lipoprotein receptor-related protein-1 (LRP1) with intestinal inflammation. Therefore, we intended to explore the relationship of LC...
M. Hasan, Md. Amran Gazi, Subhasish Das et al.· BMJ Paediatrics Open· 6 citations
Escherichia coli (E. coli) pathotypes are the most common cause of diarrhea, especially in developing countries. Environmental Enteric Dysfunction (EED) is presumed to be the result of infection with one or more pathotypes and can affect intestinal health and childhood growth. We sought to investigate the association o...
Md. Amran Gazi, M. Alam, S. M. Fahim et al.· Frontiers in Cellular and In...· 19 citations· ⚡2
Infections and persistent immunological activation are linked to increased kynurenine (KYN) and the KYN-to-Tryptophan (TRP) or KT ratio and may be critical factors in undernutrition. We sought to determine the association between the KT ratio and adult malnutrition, as well as investigate if nutritional supplementation...
Md. Amran Gazi, M. A. Siddique, M. Alam et al.· Nutrients· 4 citations
Dysregulations in the mammalian target of rapamycin (mTOR) pathway are associated with several human anomalies. We aimed to elucidate possible implications for potential aberrations in the mTOR pathway with childhood malnutrition. We analyzed the activity of phospho-mTORC1 and the expressions of several mTOR pathway ge...
P. Palit, Md. Amran Gazi, Subhasish Das et al.· Nutrients· 5 citations
We conducted an observational study to assess the prevalence and risk factors of vitamin D deficiency in 12–24 months old children living in urban and rural Bangladesh. Serum 25-hydroxyvitamin D (free 25(OH)D) level, socio-demographic status, anthropometric status, dietary intake, exposure to sunlight and single nucleo...
Subhasish Das, M. Hasan, Minhazul Mohsin et al.· Scientific Reports· 20 citations· ⚡3
In the current world, a major challenge to diagnose environmental enteric dysfunction (EED) is the lack of validated non-invasive biomarkers. Intestine derived molecules, including intestinal fatty acid binding protein (I-FABP), trefoil factor-3 (TFF3), lactoferrin, lipocalin-2 (LCN2), and mucin-2, have been reported a...
M. Hasan, Md. Amran Gazi, Subhasish Das et al.· Scientific Reports· 12 citations· ⚡4
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