Author

T. Andresson

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Open access Sep 2026

SMYD3 protein degraders in HPV-negative head and neck squamous cell carcinoma

Despite the advent of immunotherapy in the treatment of human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma, the overall prognosis still remains dismal. Novel therapeutic approaches are thus urgently needed. We recently reported that SET and MYND containing 3 (SMYD3), a protein methyltransferase...

Jawad Akhtar, Sai Reddy Doda, William J. Moore et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.

PAK1 and PAK2 shielded RAS from LZTR1-dependent degradation by phosphorylating T148, and inhibiting PAK1/2 activity improved RAS-directed therapy, revealing a regulatory circuit governing RAS stability that is preferentially active in blood cancers and potentially druggable.

Lin Zhang, A. Bolomsky, Omar S. Al-Odat et al. · Blood Cancer Discovery · 0 citations