Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau...
I. Bizzi, Arthur C. Macedo, Lydia Trudel et al.· Alzheimer's & Dementia· 0 citations
It is shown that elevated plasma GFAP significantly modulates the association between p-tau217 and both cross-sectional cognitive severity and longitudinal clinical decline, and support that astrocyte reactivity is associated with greater cognitive impairment and faster clinical decline among individuals with elevated...
B. Bellaver, G. Povala, P. C. L. Ferreira et al.· Molecular Neurodegeneration· 0 citations
It is suggested that hippocampal 18F-MK6240 uptake may represent a candidate marker of circuit vulnerability associated with NREM sleep-memory dysfunction in TLE, warranting validation in larger longitudinal studies.
Thaera Arafat, Katharina Schiller, J. Lam et al.· bioRxiv· 0 citations
This multicohort study demonstrated how including additional plasma proteins significantly enhanced the performance of p-tau217 in predicting advanced tau pathology among amyloid-positive individuals, suggesting a multiprotein approach may offer a viable and scalable alternative to tau PET staging in clinical or resear...
Guglielmo di Molfetta, W. Brum, I. Pola et al.· JAMA Neurology· 1 citation
The extensive proteome remodeling in the (p)ppGpp-null relA spoT mutant during late exponential and stationary phase and the first protein-level analysis of the stringent response in P. aeruginosa are characterized, highlighting the role of (p)ppGpp in shutting down broad metabolic functions and activating adaptive pat...
Jacquelyn Rich, Samuel J. T. Wardell, D. Martins et al.· mSystems· 0 citations
Across regions and networks, SEOT performed similarly or better than tau load in predicting metabolic dysfunction and may improve diagnostic characterisation and prediction of cognitive impairment beyond [18F]FDG-PET.
Arthur C. Macedo, Lydia Trudel, S. A. Hosseini et al.· EBioMedicine· 1 citation
