Abstract Background Clear cell renal cell carcinoma (ccRCC) with sarcomatoid differentiation (sRCC) is associated with poor survival. Recent studies have shown downregulation of hypoxia-related pathways in sRCC (Motzer et al., Cancer Cell, 2020; El Zarif, Semaan et al., Cell Reports, 2024). In this study, we sought to...
R. Nawfal, É. Ibrahim, K. Semaan et al.· The Oncologist· 0 citations
Abstract Background Hypoxia signaling is a key driver of renal cell carcinoma (RCC) and is mediated by HIF-dependent transcription. ARNT (HIF-1β) is an essential HIF binding partner, but its expression and clinical relevance in RCC are poorly defined. With ARNT inhibitors in development, characterizing ARNT expression...
Yu-Wei Chen, S. Nazari, A. Elliott et al.· The Oncologist· 0 citations
Across three cohorts, higher ARNT expression correlated with higher BHS, and a consistent correlation was observed between ARNT and EPAS1 and HIF1A expressions, and a consistent correlation was observed between ARNT and EPAS1 expressions.
Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad et al.· The Oncologist· 0 citations
An in vitro RCC antigen model system was established to evaluate the impact of belzutifan on T-cell cytotoxicity and revealed that IL-2 and IFNG were among the most significantly downregulated genes in HIF2α knockout T cells.
S. Kashima, Katrine N. Madsen, H. Soulati et al.· The Oncologist· 0 citations
Renal cell carcinomas (RCC) comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes and chromatin accessibility profile...
Prathyusha Konda, Alexandra J. Wakolbinger, Yan-Tong Cui et al.· Nature Communications· 0 citations
A tissue residency gene program in Tex cells associated with non-response to immunotherapy was identified and nominates resident memory exhausted CD8+ T cells as a targetable subset of cells to improve CD8+ T cell-mediated anti-tumor immunity.
Rishabh Rout, S. Kashima, M. Hugaboom et al.· The Oncologist· 0 citations
The findings suggest an ECM–CD44 axis linking tumor mesenchymal programs to M2-like polarization and increased macrophage infiltration in stromal and sarcomatoid areas compared to clear cell regions.
Katsuhiro Ito, S. Kashima, Rishabh Rout et al.· The Oncologist· 0 citations
It is found that baseline tumor infiltration by exhausted T cells with a resident memory phenotype (Tex-rm) is significantly associated with worse PFS in advanced RCC patients receiving ICI monotherapy or ICI+TKI combination therapy.
Zhao-Chen Ye, S. Kashima, Rishabh Rout et al.· The Oncologist· 0 citations
Abstract Background Renal cell carcinoma (RCC) is characterized by an immunogenic tumor microenvironment and frequent activation of angiogenic pathways. Therefore, combining immune checkpoint blockade with VEGF pathway inhibition is a rational therapeutic approach. PF‑08634404 is an investigational anti–PD‑1 and anti‑V...
T. Choueiri, S. Pal, T. Powles et al.· The Oncologist· 0 citations
Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.
Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al.· Nature· 2 citations
It is demonstrated that machine learning applied to transcriptomic data can uncover novel cancer vulnerabilities and actionable targets in individual tumors, even in the absence of functional screening, which may represent a scalable approach to advance precision oncology in rare and/or under-characterized cancer types...
Ananthan Sadagopan, Bingchen Li, Jiao Li et al.· Cancer Research· 0 citations
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