Author

T. Grimmer

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Open access Jul 2026

Deep learning‐based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study

Abstract INTRODUCTION Cortical atrophy patterns on magnetic resonance imaging (MRI) are essential for diagnosing neurodegenerative diseases (NDs), but remain challenging to assess visually. Deep learning enables quantitative evaluation of cortical thickness (CTh) and z‐score maps. METHODS 3T three‐dimensional T1 MRI fr...

E. Riedel, Fabian Bongratz, B. Zott et al. · Alzheimer's & Dementia · 0 citations

Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · Nature Genetics · 0 citations