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Open access Sep 2026

Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder

Key Points Question Are gray matter volume (GMV) trajectories over the long-term course of major depressive disorder (MDD) associated with cumulative or acute illness severity? Findings In this 10-year case-control study including 206 participants, fronto-limbic GMV changes were significantly associated with individual...

A. Kraus, J. Goltermann, T. Borgers et al. · 0 citations
Sep 2026

Cognitive Reserve as a Stratification Factor for Cognitive Impairment and Disease Progression in Major Depressive Disorder.

The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.

M. Gruber, Henrike Renaud, M. Mauritz et al. · 0 citations
Open access Aug 2026

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.

Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al. · 0 citations

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