Methotrexate (MTX) is widely used in treating chronic inflammatory diseases and in chemotherapy for both adult and pediatric patients. Its pharmacokinetics are complex, as MTX is a substrate of multiple transporters. Particularly during high-dose chemotherapeutic use, it is associated with severe toxicities including r...
C. Dette, F. Marok, Veronika Alberg et al.· Scientific Reports· 0 citations
A PBTK model was developed for 5FC and its primary metabolite N-pentanoic acid in pigs and translated to humans for predicting systemic and tissue-specific exposure and generated exploratory human systemic and tissue exposure predictions.
Omar Zaher, D. Selzer, H. Loer et al.· Archives of Toxicology· 0 citations
While pharmacodynamic and pharmacokinetic drug-drug interactions are well established, physicochemical interactions between co-administered oral drug products and their impact on drug absorption remain poorly understood. This study combined biorelevant in vitro testing and physiologically based pharmacokinetic (PBPK) m...
Christopher Hauß, Denise Feick, D. Selzer et al.· International journal of pha...· 0 citations
Abstract Polypharmacy is a major risk factor for adverse drug events (ADEs), particularly when drug-drug and drug- gene interactions are insufficiently considered in routine care. The EU-funded SafePolyMed project addresses this challenge by developing a digital Medication Management Center (MMC) that integrates pharma...
Sabine C. Gepp, F. Schera, F. Marok et al.· Current Directions in Biomed...· 0 citations
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