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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

T. Wyss-Coray

h-index 103 View on Semantic Scholar

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#protein folding Sep 2026

“Sex-divergent responses to microglial depletion suggest distinct regulatory dependencies in the aged brain”

Microglia are essential for brain homeostasis, yet their roles in the aged brain remain poorly defined. Using microRNA (miRNA) profiling, cellular-resolution spatial transcriptomics, and bulk proteomics in 21-month-old mice, we characterize sex-dimorphic responses to microglial depletion via CSF1R inhibition (PLX5622 t...

Amila Beganovic, M. Flotho, Jin-Xiu Li et al. · 0 citations
Open access Aug 2026

Core activation program and selective regional responsiveness of microglia during aging and parabiosis.

Aging is associated with immune dysregulation in the brain and is the greatest risk factor for many neurodegenerative diseases. Rejuvenation interventions can mediate beneficial effects. Microglia are major contributors to neurodegenerative disease progression; however, the molecular changes underlying brain aging and...

H. Naz, Nannan Lu, Caroline C. Escoubas et al. · 0 citations
Open access Aug 2026

Alzheimers disease blood biomarkers reveal proteomic modules of disease progression

Routine and accessible plasma measures can be leveraged to recover reproducible, biologically distinct progression modules that improve characterization of heterogeneous AD and have practical value for risk stratification, trial enrichment, or treatment monitoring.

R. R. Butler, M. Brown, A. Weber et al. · 1 citation

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