Takahiro K. Fujiwara

Cis glycan–glycan interactions organize membrane nanodomains that tune receptor signaling

The plasma membrane (PM) is generally viewed as organized by coordinated interactions among proteins and lipids, largely overlooking the cell’s most extensive surface chemistry, the glycan layer. Here, we directly detect specific cis glycan–glycan interactions using single-molecule imaging of 39 chemically synthesized...

Analytical methodology for unveiling the physical effect of detergents on the function of full-length membrane proteins using a single-molecule tracking system