Tatsuya Akiyama

Bacteriostatic lethality emerges from turgor-induced physiological stress

It is found that translation inhibition by bacteriostatic antibiotics induces intracellular turgor pressure buildup by perturbing physiological balance in E. coli, showing bacteriostasis as a physiologically unstable state and providing a systems-level framework for its lethality, enabling the rational design of optimi...