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Author

Taufiq Rahman

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Open access Aug 2026

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

This article shows that this plasticity is governed by a distal allosteric network that allows TPC2 to discriminate between agonists and generate specific lysosomal ion fluxes, and Mutant channels exhibit enhanced Ca²⁺ permeability and adopt a co-activated-like state.

Qian-Ru Mu, Ryo Saito, Franceska Ozola et al. · 0 citations
#protein folding Open access Aug 2026

Benchmarking protein-ligand co-folding across Nav, Cav and Kv-family channels

Results show that current co-folding methods remain unreliable as stand-alone predictors of ion-channel ligand-binding modes and highlight pose sampling, pocket selection, ligand representation and independent structural validation as priorities for methodological development.

Yu Zhu, Taufiq Rahman · 0 citations

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