Antimicrobial resistance is a critical global health threat, as conventional antibiotics are increasingly ineffective against multidrug-resistant (MDR) pathogens, particularly ESKAPE organisms. In response, bacteriophages and their derived lytic proteins, including endolysins, holins, and spanins, have emerged as promi...
Moses Mwangi, Grace Gitau, F. Musila et al.· Applied microbiology· 0 citations
This study sought to identify peptides that mimic the substrates of PfGrp78, which can be potential inhibitors of PfGrp78, and explored the mechanism of action of cyclodecapeptides, gramicidin S (GS) and tyrocidines (Trcs), which were previously shown to exhibit potent antimalarial activity.
Wendy Mthembu, A. Odugbemi, F. L. Muzenda et al.· Journal of Computer-Aided Mo...· 0 citations
PfPDI inhibitors are most likely to succeed as components of resistance-robust combination therapies, and progress will depend on structure-guided targeting of divergent non-catalytic surfaces, optimization of intracellular and ER exposure, and rigorous in-parasite target-engagement studies.
A. Odugbemi, Wendy Mthembu, Tawanda Zininga· Expert opinion on therapeuti...· 0 citations
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