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Author

Taylor J. Ellison

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Open access Sep 2026

Neural Stem Cell‐Derived Extracellular Vesicles Improve CNS Delivery and Therapeutic Efficacy of Antisense Oligonucleotide in Amyotrophic Lateral Sclerosis

Findings provide proof‐of‐concept evidence supporting the potential of NSC‐EV as a promising platform that not only enhances CNS delivery of ASOs but also contributes to overall therapeutic activity, offering a synergistic strategy to advance nucleic acid therapeutics for ALS and potentially other neurological diseases...

Yao-Chao Zheng, Taylor J. Ellison, Robert Garrard et al. · 0 citations
Open access Mar 2026

A broad-spectrum phage-encoded mechanism to disarm bacterial type IV filaments

It is shown that despite originating from a P. aeruginosa-specific phage, Aqs1 can also disable T4 ATPase-dependent phenotypes across other pathogenic bacteria and homologous systems and provides a design template for broad-spectrum inhibitors of diverse bacterial virulence factors.

Nathan Roberge, Paankhi Dave, Véronique L. Taylor et al. · 0 citations
#protein folding Open access Aug 2026

β-strand addition within tip initiation complexes licenses assembly of diverse type IV filaments

How PilC/PilY1 can be retained on the fiber tip under enormous tensile loads generated during mechanical shear and T4P retraction is explained and how diverse T4P systems employ β-strand addition to license fiber assembly is demonstrated.

Taylor J. Ellison, Zoey R. Litt, Justin N. Applegate et al. · 0 citations

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