Author

Theodore P. Braun

2 papers indexed here

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Sep 2026

CSF3R compound mutations produce a hyperproliferative leukemia driven by overexpression of PIM kinases.

Colony Stimulating Factor 3 Receptor (CSF3R) mutations are the molecular hallmark of chronic neutrophilic leukemia (CNL). A subset of these patients (~25%) have two mutations in CSF3R on the same allele. These "compound" CSF3R mutations include both an activating point mutation and a cytoplasmic truncating mutation. Wh...

Breanna N. Maniaci, Jacob Edward Porter, Hanqian L. Carlson et al. · Blood · 0 citations

#gene editing Open access Sep 2026

Mutant ASXL1 Cooperates with MECOM and BRD4 to Drive Transcriptional Dysregulation in Human Hematopoiesis.

This work extensively characterized a CRISPR-engineered human hematopoietic stem and progenitor cell model of ASXL1 mutations, and is the first to functionally describe the mutant ASXL1 interactome in the context of human HSCs, identifying MECOM and BRD4 as actionable dependencies with therapeutic potential for ASXL1-m...

Madison L. Hall, Aliya Quintal, Sonia N. Acharya et al. · Blood · 0 citations