Prime editing enables high-throughput identification and characterization of selective MutSβ inhibitors
This effort identified a novel series of MutSβ inhibitors that reduced (CAG)n expansion in a cell model and established several methods for systematically interrogating MMR, with demonstrated capacity to identify inhibitors of therapeutic value.
Yangwode Jing, Jun Yan, Denny Yang et al.
· bioRxiv · 0 citations