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Tian-Yun Wang

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#protein folding Sep 2026

A Non-Conventional Epigenetic Engineering Strategy: The ALKBH5/ITGB5 Axis Enhances Recombinant Protein Production in CHO Cells through FAK-Mediated Proliferation and Improved Redox Status

ALKBH5 is identified as a candidate host-cell engineering target for improving recombinant protein production and support further validation under industry-relevant fed-batch conditions.

Zhao-Ming Cui, Jiang-Tao Lu, Yan-Ping Gao et al. · 0 citations
Review Open access Aug 2026

Improving recombinant protein productivity in CHO cells via multi-omics data integration

Chinese hamster ovary (CHO) cells represent the dominant host system for the production of recombinant therapeutic proteins. In recent decades, extensive research has focused on process/media optimization and cell line engineering to improve both the productivity and quality of biopharmaceutical proteins produced in CH...

Yuan Shen, Lei Shi, Xi Zhang et al. · 0 citations

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