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Open access Aug 2026

Metabolomics and Machine Learning Uncover 5′-Methylthioadenosine as a Metabolic Indicator of Mixed-Pattern Drug-Induced Liver Injury

MTA emerges as an exploratory biomarker that uncovers the distinct metabolic trajectories hidden within mixed-pattern DILI, and these findings highlight the MTA-methylthioadenosine phosphorylase phosphorylase (MTAP) axis as a potential mechanistic driver of cholestatic injury.

Jing-Hui Zhang, Hong-Chuan Liu, Qi Qiu et al. · 0 citations
#protein folding Open access Sep 2026

Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies

Background Venetoclax and selinexor are essential targeted agents for hematological malignancies, but their clinical application is challenged by pronounced ethnic pharmacokinetic differences—especially in Chinese patients—and CYP3A-mediated drug-drug interactions (DDIs) with azole antifungals (voriconazole, fluconazol...

Fei-Fei Han, Yin-Ying Wang, Y. Jian et al. · 0 citations

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