Review
Aug 2026
Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives
SIRT1, SIRT3 and SIRT6 act as core cardioprotective subtypes: they synergistically activate the AMPK/Nrf2 antioxidant axis to block reperfusion oxidative injury and form an integrated endogenous protective network targeting all core pathological links of MIRI.
Tingting Xue, Shu Wang, Xin-Yu Zhu et al.
· Molecular Biology Reports · 1 citation