Protective mechanisms of Sirtuin Family in myocardial ischemia-reperfusion injury and translational therapeutic perspectives

Myocardial Ischemia-Reperfusion Injury: Molecular Mechanisms and Innovative Therapeutic Strategies

Myocardial ischemia–reperfusion injury (MIRI) is a critical pathological paradox following revascularization in acute myocardial infarction, yet effective clinical interventions remain limited. MIRI involves a complex, interlinked hierarchy of programmed cell death modalities, including ferroptosis, pyroptosis, and cup...

Quercetin in Myocardial Ischemia–Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges

Myocardial ischemia–reperfusion (I/R) injury remains a major limitation in cardiovascular therapy, where restoration of blood flow paradoxically initiates oxidative stress, inflammation, mitochondrial dysfunction, and cardiomyocyte death. Although multiple pharmacological strategies have been investigated, clinical tra...

Pyroptosis in myocardial ischemia-reperfusion injury: mechanistic pathways and therapeutic prospects

Acute myocardial infarction (AMI) remains the leading cause of cardiovascular death and disability worldwide. With the advances in percutaneous coronary intervention and coronary artery bypass grafting, timely revascularization has become the main approach to limit infarct size and improve heart function and prognosis....

Metabolism-Gated Cell Death Switching in Myocardial Ischemia-Reperfusion Injury: From Regulated Death Networks to Precision Cardioprotection

Myocardial ischemia–reperfusion injury (MIRI) is driven by dynamic metabolic disturbances that extend beyond adenosine triphosphate depletion and encompass mitochondrial dysfunction, redox imbalance, calcium overload, iron dysregulation, lipid peroxidation, and inflammatory activation. These alterations regulate multip...

GSK-3β in myocardial ischemia-reperfusion injury: molecular insights and therapeutic approaches.

Imbalance of the Regulated Cell Death and Autophagic Network: A Core Mechanism Driving Toxicological and Ischemic Myocardial Injury and a Target for Intervention with Traditional Chinese Medicine