Open access
Oct 2026
Characterization of MdDOX-Co homologs revealed a novel gibberellin metabolic clade and a single-residue switch dictating the catalytic site.
The metabolism of gibberellin (GA) is generally mediated by GA 2-oxidase (GA2ox) through 2β-hydroxylation. These enzymes belong to the 2-oxoglutarate-dependent dioxygenase (2ODD, DOX) superfamily. However, MdDOX-Co, another 2ODD, was recently found to catalyze atypical GA 12α-hydroxylation. MdDOX-Co belongs to the DOXC...
Taiki Inoue, Yusaku Karasuno, T. Wakabayashi et al.
· Biochimie · 0 citations