Multiplex programming of mappable, molecularly tagged genomic deletions
Conventional CRISPR knockout screens target genes via focal indels that readily disrupt open reading frames (ORFs). However, their utility for targeting candidate cis-regulatory elements remains limited, as focal indels cannot abrogate enhancer activity with high confidence. Compounding this limitation, conventional CR...
Aidan Keith, R. Daza, Jonas Koeppel et al.
· bioRxiv · 0 citations