A Small Molecule Substrate Mimic to Inhibit Bacterial Hsp70 Chaperone Function.
Given the rapid spread of antibiotic resistance worldwide, it is imperative to develop new strategies against pathogenic bacteria. Here, we report a small-molecule inhibitor of bacterial heat shock protein 70 (Hsp70), called DnaK, a central component of the bacterial protein chaperone network. Screening of an in-house...
Tulsi Upadhyay, Reshma Kumari, Yogesh M. Gangarde et al.
· ChemBioChem · 0 citations