Amyotrophic lateral sclerosis (ALS) is a severe disease that causes thousands of deaths annually. Current treatments are either limited in effectiveness or not broadly applicable. To discover new options, we conducted a genetics-based screen to identify drugs that could be repurposed for ALS. We analyzed genome-wid...
S. Saez-Atienzar, Luis A. Rojas-Colón, Ruth Chia et al.· npj Digital Medicine· 0 citations
A new model is developed that is validated across diverse ALS populations, can handle discrepancies between genotyping technologies, and is applicable to individual external samples, and has the potential to extend genetic risk assessment to all individuals, regardless of their family history or the presence of known A...
Jia-Jing Hu, Oliver Pain, A. Al Khleifat et al.· Genome Medicine· 0 citations
The utility of multiple proteins reflecting diverse biological pathways in refining survival stratification is indicates the utility of multiple proteins reflecting diverse biological pathways in refining survival stratification and highlights systemic factors in ALS progression.
H. Klimovski, M. Weinreich, A. Strange et al.· medRxiv· 0 citations
This work indicates the utility of multiple proteins reflecting diverse biological pathways in refining survival stratification and highlights systemic factors in ALS progression, highlighting their potential role in measuring disease progression.
D. Lester, P. Piazza, E. Dellar et al.· medRxiv· 0 citations
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