The utility of multiple proteins reflecting diverse biological pathways in refining survival stratification is indicates the utility of multiple proteins reflecting diverse biological pathways in refining survival stratification and highlights systemic factors in ALS progression.
Cell-type enrichment analysis indicating a broad cellular origin of the circulating proteome, with contributions from nervous system cells, vascular cells, immune cells, and muscle cells, highlights the potential of plasma proteomics for clinically meaningful patient stratification in ALS.
I. Aksoylu, L. Azizi, L. OÌijerstedt et al.· medRxiv· 0 citations
Investigating whether alterations in six previously MS-associated biomarkers are detectable and associated with underlying genetic susceptibility in two independent sample collections suggest that several circulating proteins recently proposed as MS biomarkers are not robust tools to distinguish MS from healthy individ...
Kristin Mounts, Yun-Duo Liu, Masashi Fujita et al.· Multiple Sclerosis and Relat...· 0 citations
The results indicate and confirm that TNFRSF8 is highly dysregulated in HDGECs and also tracks clinical disease progression, and may be a promising potential target for DMTs.
Helga Maria Grétarsdóttir, Janet L. Cunningham, A. Rasmusson et al.· Journal of Neurology· 0 citations
It is suggested that serum GFAP may serve as a biomarker for personalized risk stratification and treatment monitoring and as a screening tool to reduce cohort size in clinical trials targeting MS progression.
M. Einsiedler, S. Sandgren, S. Schaedelin et al.· JAMA Neurology· 0 citations
Findings show that a non-invasive plasma multi-analyte panel can differentiate MSA from PD with clinically meaningful accuracy, and support prospective validation in larger cohorts.
ALS exhibits a measurable molecular prodrome detectable in blood years before diagnosis, and integrated proteomic and genetic profiling may support early identification and trial enrichment strategies.
S. Lehrer, P. Rheinstein· Journal of Clinical Neuromus...· 0 citations
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