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V. Kushnirov

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Open access Sep 2026

Cryo-EM structure of ex vivo Sup35 yeast prion and the factors defining prion phenotype

Human prions and amyloids exhibit structural diversity that correlates with different pathological manifestations. Yeast prions represent a convenient model for studying fundamental properties of prions and their strain diversity. The Sup35 yeast prion has multiple structural variants, divided into “strong” and “weak...

A. A. Dergalev, Y. Chesnokov, A. Burtseva et al. · 0 citations
Open access Aug 2026

The conserved β-hairpin of the SUI1 domain is a dual-function structural module governing translation initiation and ribosome recycling in yeast

The β-hairpin loop 1 of the DENR/Tma22p SUI1 domain is established as a critical determinant for ribosome recycling and reinitiation, and raise the question of whether MCTS1/Tma20p can promiscuously operate with either DENR/Tma22p or eIF1/Sui1p – two specialized factors that evolved from a common structural scaffold to...

Kseniya A. Zamyatnina, V. Urakov, I. А. Volynkina et al. · 0 citations

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