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V. Menachery

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Open access Sep 2026

Longitudinal dynamics and lineage cross-reactivity of the human antibody response to West Nile virus

ABSTRACT West Nile virus (WNV) is an emerging/re-emerging flavivirus representing one of the major global causes of mosquito-borne encephalitis, yet no approved therapeutics or vaccines currently exist. To characterize the kinetics of WNV-specific immunity, we evaluated the humoral response in a longitudinal cohort of...

Austin G. Leach, Ling-Ling Xu, Shilu Malakar et al. · 0 citations
Open access Sep 2026

Antagonism of stress granules is key to SARS-CoV-2 infection and pathogenesis

ABSTRACT Viruses must subvert host responses to facilitate successful infection. While most antiviral responses are associated with interferons, stress granules (SGs) are another barrier to viral infection by inducing translation arrest. To combat SG activity, viruses have evolved mechanisms to disrupt formation and di...

R. E. Alvarado, Jennifer Chen, Kumari G. Lokugamage et al. · 0 citations
#protein folding Open access Aug 2026

Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses

Data indicate the KP.2 mRNA vaccine generates durable, cross-reactive responses against current Omicron subvariants, however, ongoing spike evolution impacts the neutralization of emerging lineages, highlighting the need for continued viral monitoring and timely vaccine updates.

Sanjeev Kumar, Li-Lin Lai, M. Ellis et al. · 0 citations

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